Niemann-Pick A (NPA) disease is a lysosomal storage disorder (LSD) caused by a deficiency in acid sphingomyelinase (ASM) activity.Previously, we reported that biochemical and functional abnormalities observed in ASM knockout (ASMKO) mice could be partially alleviated by intracerebroventricular (ICV) infusion of hASM.We now show that this route of d
Graphical AbstractAMD, age-related macular degeneration; Nail Clippers PCV, polypoidal choroidal vasculopathy; PLS-DA, partial least squares discriminant analysis; LPC, lysophosphatidylcholine; PC, phosphocholine; ROC, operating characteristic curve; AUC, area under the Stove Burner Cap receiver operating characteristic curve; vWF, von Willebrand F
The feral domestic cat (Felis catus) is a predatory invasive species with documented negative effects on native wildlife.The issue of appropriate and acceptable feral cat management is a matter of contentious debate in cities and states across the United States due to concerns for wildlife conservation, cat welfare, and public health.Common managem
This paper offers an answer to the following question: is the government authorized to intervene into the field of the religious freedom during the state of emergency, declared under the pressure of the ongoing epidemics, given the fact that the particular religious ritual - the holy communion - presupposes an epidemiologically risky practice.The m
The outbreak of Coronavirus Disease 2019 (COVID-19) has caused increasing challenges for healthcare systems globally.The disease spread rapidly from Wuhan to the rest of the world, involving more than 400 million individuals and including more than 5 million deaths.In dealing with the pandemic, China and other countries took protective measures suc