COMPARATIVE ANALYSIS OF ACID SPHINGOMYELINASE DISTRIBUTION IN THE CNS OF RATS AND MICE FOLLOWING INTRACEREBROVENTRICULAR DELIVERY.

Comparative analysis of acid sphingomyelinase distribution in the CNS of rats and mice following intracerebroventricular delivery.

Niemann-Pick A (NPA) disease is a lysosomal storage disorder (LSD) caused by a deficiency in acid sphingomyelinase (ASM) activity.Previously, we reported that biochemical and functional abnormalities observed in ASM knockout (ASMKO) mice could be partially alleviated by intracerebroventricular (ICV) infusion of hASM.We now show that this route of d

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Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

Graphical AbstractAMD, age-related macular degeneration; Nail Clippers PCV, polypoidal choroidal vasculopathy; PLS-DA, partial least squares discriminant analysis; LPC, lysophosphatidylcholine; PC, phosphocholine; ROC, operating characteristic curve; AUC, area under the Stove Burner Cap receiver operating characteristic curve; vWF, von Willebrand F

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Walking a tightrope: On the constitutionality of limiting freedom of worship under the state of emergency declared in the Republic of Serbia caused by the epidemic of Covid-19

This paper offers an answer to the following question: is the government authorized to intervene into the field of the religious freedom during the state of emergency, declared under the pressure of the ongoing epidemics, given the fact that the particular religious ritual - the holy communion - presupposes an epidemiologically risky practice.The m

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